NAALADL1

Across TCGA pan-cancer cohorts, NAALADL1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of NAALADL1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where NAALADL1 RNA is repressed in tumor relative to normal tissue. In most cancer types NAALADL1 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KICH, and BLCA are the cancer types where NAALADL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NAALADL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−2.588	<.001	11	view →
KICH	Female	All	−1.539	<.001	10	view →
BLCA	Male	III,IV	−1.258	<.001	10	view →
LUSC	Male	III,IV	−1.775	<.001	8	view →
LUAD	Female	III,IV	−1.091	<.001	8	view →
UCEC	All	III,IV	−2.217	<.001	6	view →
BRCA	All	II,III,IV	−0.959	<.001	6	view →
KIRP	Male	II,III,IV	−0.864	<.001	6	view →
LIHC	Female	All	+0.856	<.001	6	view →
READ	All	All	−2.091	<.001	5	view →
KIRC	All	All	+0.252	.001	3	view →
STAD	All	All	−0.921	.029	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

NAALADL1–COAD

Open the COAD breakdown →