NAALADL1

Across TCGA cell cohorts, NAALADL1 mutation is significantly associated with the RNA expression of many other genes, with 199 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NAALADL1-associated genes across cancer lineages are OR4X2, PRAMEF25, and FERD3L. Each is linked with NAALADL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NAALADL1-to-partner and partner-to-NAALADL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4X2 grouped by NAALADL1-low versus NAALADL1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAALADL1→partner) and Y-score (partner→NAALADL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR4X2 →	+0.102	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	PRAMEF25 →	+0.015	+4.867	<.001	.009	3	1
BLOOD_Leukemia	FERD3L →	+0.032	+5.969	<.001	.001	3	1
BLOOD_Leukemia	SLC22A24 →	+0.102	+5.969	<.001	.001	3	1
BLOOD_Leukemia	SMIM28 →	+1.160	+6.569	<.001	<.001	3	1
SKIN	GOLGA6L22 →	+0.004	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 199 associations by consensus.

OR4X2 by NAALADL1 expression — BLOOD_Lymphoma

Explore this box plot interactively →