NAA16

Across TCGA pan-cancer cohorts, NAA16 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated NAA16 data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher NAA16 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NAA16 expression acts as an unfavorable survival marker, although some lineages such as MESO and UCEC show a favorable association.

KICH, MESO, and ACC are the cancer types where NAA16 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	All	0.666	0.970	.004	54	view →
MESO	OS	Median	II,III,IV	0.672	0.452	.005	42	view →
ACC	DFS	Tertile	All	0.431	0.773	.003	35	view →
UCEC	DFS	Tertile	III,IV	0.848	0.678	.020	32	view →
UVM	OS	Quartile	III,IV	0.310	0.925	.004	32	view →
CESC	DFS	Tertile	III,IV	0.212	0.804	.005	30	view →
KIRP	DFS	Median	IV	0.039	0.524	.002	25	view →
GBM	DFS	Tertile	All	0.489	0.171	<.001	23	view →
UCS	DFS	Tertile	IV	0.906	0.418	.024	20	view →
KIRC	DFS	Median	III,IV	0.730	0.532	.031	13	view →
ESCA	OS	Median	IV	0.222	0.698	.006	12	view →
BRCA	DFS	Quartile	III,IV	0.980	0.831	.011	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

NAA16–KICH (DFS)

Open the KICH breakdown →