NAA16

Across TCGA pan-cancer cohorts, NAA16 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of NAA16’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where NAA16 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NAA16 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

COAD, LIHC, and THCA are the cancer types where NAA16 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NAA16 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	+0.946	<.001	10	view →
LIHC	All	II,III,IV	+0.551	<.001	8	view →
THCA	All	II,III,IV	−0.466	<.001	8	view →
KICH	Female	All	−0.876	<.001	6	view →
CHOL	Male	All	+1.540	<.001	4	view →
READ	All	III,IV	+1.035	.006	4	view →
STAD	All	IV	+0.643	.017	4	view →
UCEC	All	All	−0.500	.001	4	view →
LUAD	Female	II,III,IV	−0.486	.002	4	view →
BRCA	Female	All	−0.237	.004	4	view →
ESCA	All	All	+0.552	.006	2	view →
PRAD	All	All	−0.248	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

NAA16–COAD

Open the COAD breakdown →