N4BP2L2

Across TCGA patient cohorts, N4BP2L2 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible N4BP2L2-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and Src_pY527. Each is linked with N4BP2L2 in more than 2 cancer types. Because this analysis shows association rather than direction, both N4BP2L2-to-partner and partner-to-N4BP2L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by N4BP2L2-low versus N4BP2L2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (N4BP2L2→partner) and Y-score (partner→N4BP2L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.383	-1.571	.003	.032	3	3
COAD	Caspase-7-cleavedD198 →	+1.139	+3.016	.001	.018	3	3
COAD	Src_pY527 →	-0.525	-2.313	.003	.035	3	3
UCEC	EGFR_pY1068 →	-0.199	-1.847	.005	.007	3	2
UCEC	FoxM1 →	+0.240	+2.192	.001	<.001	3	2
UCEC	INPP4B →	-0.197	-1.847	.034	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

ATM by N4BP2L2 expression — UCEC

Explore this box plot interactively →