N4BP2L2

Across TCGA pan-cancer cohorts, N4BP2L2 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated N4BP2L2 data layer compared with 8 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher N4BP2L2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated N4BP2L2 expression acts as an unfavorable survival marker, although some lineages such as SKCM and MESO show a favorable association.

CESC, UVM, and ACC are the cancer types where N4BP2L2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	III,IV	0.417	0.798	<.001	90	view →
UVM	DFS	Quartile	III,IV	0.183	0.900	<.001	67	view →
ACC	DFS	Tertile	All	0.385	0.738	.019	28	view →
SKCM	OS	Median	III,IV	0.533	0.263	.004	27	view →
READ	DFS	Tertile	II,III,IV	0.452	0.776	.022	21	view →
MESO	OS	Median	III,IV	0.516	0.308	.013	19	view →
PAAD	OS	Median	All	0.582	0.407	.020	12	view →
BRCA	OS	Median	III,IV	0.949	0.854	.009	12	view →
ESCA	OS	Median	IV	0.222	0.698	.006	12	view →
UCS	DFS	Tertile	IV	0.906	0.418	.024	12	view →
LGG	DFS	Quartile	All	0.317	0.626	.007	11	view →
KICH	DFS	Tertile	All	0.654	0.923	.023	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

N4BP2L2–CESC (DFS)

Open the CESC breakdown →