N4BP2L2-IT2

Across TCGA pan-cancer cohorts, N4BP2L2-IT2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of N4BP2L2-IT2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where N4BP2L2-IT2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types N4BP2L2-IT2 is over-expressed in tumor, although a few such as BRCA and UCEC show the opposite, repressed pattern.

KIRC, BLCA, and LIHC are the cancer types where N4BP2L2-IT2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in N4BP2L2-IT2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.459	<.001	11	view →
BLCA	All	III,IV	+0.536	<.001	10	view →
LIHC	All	All	+0.173	<.001	7	view →
BRCA	Female	All	−0.295	.001	6	view →
UCEC	All	All	−0.518	<.001	4	view →
CHOL	All	All	+1.125	<.001	3	view →
READ	All	All	+0.654	.002	3	view →
KIRP	All	IV	+0.417	.028	2	view →
LUAD	All	III,IV	−0.346	.018	2	view →
COAD	All	II,III,IV	+0.303	.012	2	view →
LUSC	All	All	−0.261	.003	2	view →
STAD	All	IV	+0.243	.040	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

N4BP2L2-IT2–KIRC

Open the KIRC breakdown →