MZT2B

Across TCGA pan-cancer cohorts, MZT2B RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated MZT2B data layer compared with 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher MZT2B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MZT2B expression acts as an unfavorable survival marker, although some lineages such as UVM and BRCA show a favorable association.

KIRP, LIHC, and ACC are the cancer types where MZT2B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.813	0.963	<.001	128	view →
LIHC	OS	Median	All	0.609	0.766	<.001	101	view →
ACC	DFS	Median	All	0.213	0.728	<.001	96	view →
LUAD	DFS	Tertile	II,III,IV	0.475	0.754	.002	73	view →
COAD	OS	Tertile	III,IV	0.696	0.921	.007	39	view →
HNSC	DFS	Quartile	All	0.364	0.627	.019	29	view →
LGG	OS	Tertile	All	0.656	0.851	<.001	26	view →
UCS	DFS	Tertile	IV	0.364	0.942	.024	20	view →
PRAD	DFS	Median	All	0.899	0.965	<.001	20	view →
KIRC	OS	Tertile	All	0.820	0.911	.005	17	view →
UVM	DFS	Quartile	II,III,IV	1.000	0.536	.001	12	view →
BRCA	OS	Median	All	0.623	0.534	.026	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

MZT2B–KIRP (DFS)

Open the KIRP breakdown →