Across TCGA patient cohorts, MZT1 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MZT1-associated genes across cancer lineages are ZNF114-AS1, POTEB, and USP9YP2. Each is linked with MZT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MZT1-to-partner and partner-to-MZT1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MZT1→partner) and Y-score (partner→MZT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNF114-AS1 →	+0.500	+3.597	.006	.004	3	1
BLCA	POTEB →	+0.014	+7.640	<.001	.009	3	1
BLCA	USP9YP2 →	+0.039	+7.640	<.001	.009	3	1
UCEC	PRORY →	+0.048	+4.885	<.001	.002	3	1
UCEC	ZBTB8OSP1 →	+0.320	+2.850	.006	.007	3	1
UCEC	NPY2R →	+0.525	+2.863	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Exploration

MZT1 survival (RNA) · tumor vs normal (RNA) · all MZT1 data types