MZF1-AS1

Across TCGA pan-cancer cohorts, MZF1-AS1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of MZF1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where MZF1-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MZF1-AS1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

KIRP, LIHC, and THCA are the cancer types where MZF1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MZF1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	+0.649	<.001	10	view →
LIHC	Female	II,III,IV	+0.765	<.001	8	view →
THCA	All	All	−0.386	<.001	8	view →
COAD	All	All	+0.282	.002	7	view →
BLCA	All	All	+0.536	.008	6	view →
CHOL	Male	All	+1.106	<.001	5	view →
BRCA	All	II,III,IV	+0.183	.031	3	view →
READ	All	III,IV	+0.305	.037	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

MZF1-AS1–KIRP

Open the KIRP breakdown →