Across TCGA patient cohorts, MYT1L mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYT1L-associated genes across cancer lineages are MSH6, TFRC, and Cyclin-B1. Each is linked with MYT1L in more than 2 cancer types. Because this analysis shows association rather than direction, both MYT1L-to-partner and partner-to-MYT1L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYT1L→partner) and Y-score (partner→MYT1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MSH6 →	+0.293	+1.424	.034	.028	3	3
LUSC	TFRC →	+0.655	+1.774	.004	.008	3	3
UCEC	Cyclin-B1 →	+0.352	+1.321	.010	.024	3	3
BRCA	FOXO3a_pS318_S321 →	-0.144	-2.321	.012	.037	3	3
UCEC	ERK2 →	+0.143	+1.536	.002	.001	3	3
UCEC	Rad50 →	-0.173	-1.638	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

Exploration

MYT1L survival (RNA) · tumor vs normal (RNA) · all MYT1L data types