MYRIP

Across TCGA cell cohorts, MYRIP mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYRIP-associated genes across cancer lineages are GSX1, SAXO1, and CXCR5. Each is linked with MYRIP in more than 1 cancer types. Because this analysis shows association rather than direction, both MYRIP-to-partner and partner-to-MYRIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSX1 grouped by MYRIP-low versus MYRIP-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYRIP→partner) and Y-score (partner→MYRIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	GSX1 →	+0.006	+5.087	<.001	.004	3	1
BLOOD_Leukemia	SAXO1 →	+0.035	+3.518	.003	.008	3	1
BLOOD_Leukemia	CXCR5 →	+0.748	+3.607	<.001	.004	3	1
BLOOD_Leukemia	TMC1 →	+0.241	+2.926	<.001	.009	3	1
BLOOD_Leukemia	XCR1 →	+0.040	+3.415	<.001	.004	3	1
BLOOD_Leukemia	DEFB108B →	+0.090	+3.269	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

GSX1 by MYRIP expression — URINARY_TRACT

Explore this box plot interactively →