MYRFL

Across TCGA patient cohorts, MYRFL mutation is significantly associated with the RNA expression of many other genes, with 147 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYRFL-associated genes across cancer lineages are MIR8082, MIR6133, and ZMYND19. Each is linked with MYRFL in more than 1 cancer types. Because this analysis shows association rather than direction, both MYRFL-to-partner and partner-to-MYRFL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR8082 grouped by MYRFL-low versus MYRFL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYRFL→partner) and Y-score (partner→MYRFL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR8082 →	+0.508	+2.754	<.001	.007	3	1
UCEC	MIR6133 →	+0.501	+3.719	<.001	<.001	3	1
UCEC	ZMYND19 →	+0.598	+3.354	<.001	.005	3	1
UCEC	URM1 →	+0.551	+3.354	.001	.005	3	1
UCEC	DOLPP1 →	+0.755	+3.332	<.001	.005	3	1
UCEC	SMIM4 →	+0.717	+3.245	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 147 associations by consensus.

MIR8082 by MYRFL expression — UCEC

Explore this box plot interactively →