MYRFL

Across TCGA cell cohorts, MYRFL mutation is significantly associated with the RNA expression of many other genes, with 84 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MYRFL-associated genes across cancer lineages are TGM7, OR10G3, and OR1M1. Each is linked with MYRFL in more than 1 cancer types. Because this analysis shows association rather than direction, both MYRFL-to-partner and partner-to-MYRFL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TGM7 grouped by MYRFL-low versus MYRFL-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYRFL→partner) and Y-score (partner→MYRFL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TGM7 →	+0.013	+5.087	<.001	.004	3	1
LUNG_SCLC	OR10G3 →	+0.047	+4.643	<.001	.004	3	1
LUNG_SCLC	OR1M1 →	+0.012	+4.643	<.001	.004	3	1
LUNG_SCLC	SPATA31D1 →	+0.632	+4.643	<.001	.004	3	1
LUNG_SCLC	TEX50 →	+0.030	+4.643	<.001	.004	3	1
LARGE_INTESTINE	ASPN →	+0.064	+3.378	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 84 associations by consensus.

TGM7 by MYRFL expression — URINARY_TRACT

Explore this box plot interactively →