MYRF

Across TCGA patient cohorts, MYRF mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYRF-associated genes across cancer lineages are Cyclin-B1, Src_pY527, and MAPK_pT202_Y204. Each is linked with MYRF in more than 2 cancer types. Because this analysis shows association rather than direction, both MYRF-to-partner and partner-to-MYRF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by MYRF-low versus MYRF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYRF→partner) and Y-score (partner→MYRF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.682	+2.807	<.001	.003	3	3
LUAD	Src_pY527 →	-0.413	-3.000	.026	.035	3	2
UCEC	MAPK_pT202_Y204 →	-0.435	-2.000	.010	.009	3	2
UCEC	NDRG1_pT346 →	-0.407	-2.459	.021	.018	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.567	-2.415	<.001	.003	3	2
UCEC	PCNA →	+0.273	+3.700	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Cyclin-B1 by MYRF expression — UCEC

Explore this box plot interactively →