MYRF

Across TCGA pan-cancer cohorts, MYRF RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MYRF’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where MYRF RNA is repressed in tumor relative to normal tissue. In most cancer types MYRF is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KICH, BLCA, and LUAD are the cancer types where MYRF tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MYRF RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−2.442	<.001	10	view →
BLCA	All	All	+0.979	.005	9	view →
LUAD	Female	III,IV	−2.962	<.001	8	view →
LIHC	Female	II,III,IV	+2.198	<.001	8	view →
KIRP	All	II,III,IV	+1.166	.003	8	view →
LUSC	Female	II,III,IV	−3.817	<.001	7	view →
UCEC	All	II,III,IV	−2.117	<.001	6	view →
STAD	Male	All	+1.892	<.001	4	view →
THCA	All	All	+0.778	<.001	4	view →
CHOL	Female	All	+3.736	<.001	3	view →
KIRC	All	All	+0.523	<.001	3	view →
PRAD	All	All	−0.083	.044	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

MYRF–KICH

Open the KICH breakdown →