MYRF

Across TCGA cell cohorts, MYRF mutation is significantly associated with the RNA expression of many other genes, with 640 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MYRF-associated genes across cancer lineages are FBXW7, EDEM1, and LYG1. Each is linked with MYRF in more than 1 cancer types. Because this analysis shows association rather than direction, both MYRF-to-partner and partner-to-MYRF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBXW7 grouped by MYRF-low versus MYRF-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYRF→partner) and Y-score (partner→MYRF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FBXW7 →	+0.575	+2.628	<.001	.002	3	2
LARGE_INTESTINE	EDEM1 →	+0.575	+2.389	.003	.006	3	2
LARGE_INTESTINE	LYG1 →	+0.837	+2.628	.001	.002	3	2
BLOOD_Leukemia	PAX1 →	+0.021	+2.890	<.001	.003	3	2
BLOOD_Leukemia	APOL5 →	+0.011	+2.890	<.001	.003	3	2
BLOOD_Leukemia	AGAP2 →	+0.961	+3.259	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 640 associations by consensus.

FBXW7 by MYRF expression — LARGE_INTESTINE

Explore this box plot interactively →