MYPOP

Across TCGA patient cohorts, MYPOP mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYPOP-associated genes across cancer lineages are ACC_pS79, ACC1, and Ku80. Each is linked with MYPOP in more than 1 cancer types. Because this analysis shows association rather than direction, both MYPOP-to-partner and partner-to-MYPOP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC_pS79 grouped by MYPOP-low versus MYPOP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYPOP→partner) and Y-score (partner→MYPOP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC_pS79 →	+0.381	+2.321	.028	.035	3	1
UCEC	ACC1 →	+0.431	+2.321	.018	.035	3	1
UCEC	Ku80 →	+0.372	+2.817	.001	.036	3	1
UCEC	p62 Lck ligand →	+0.453	+3.459	.005	.005	3	1
UCEC	STAT3_pY705 →	-0.417	-3.159	.001	.019	3	1
UCEC	TIGAR →	+0.202	+2.999	.008	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

ACC_pS79 by MYPOP expression — UCEC

Explore this box plot interactively →