MYPOP

Across TCGA pan-cancer cohorts, MYPOP RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MYPOP’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MYPOP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MYPOP is over-expressed in tumor.

HNSC, LIHC, and LUSC are the cancer types where MYPOP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MYPOP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.847	<.001	12	view →
LIHC	Female	II,III,IV	+1.265	<.001	9	view →
LUSC	Female	II,III,IV	+1.254	<.001	8	view →
LUAD	All	III,IV	+0.750	<.001	8	view →
BLCA	All	All	+0.660	<.001	8	view →
COAD	Male	II,III,IV	+0.370	<.001	8	view →
STAD	Male	II,III,IV	+0.657	<.001	6	view →
BRCA	All	III,IV	+0.612	<.001	6	view →
CHOL	Male	All	+1.821	<.001	5	view →
ESCA	All	All	+0.878	<.001	3	view →
UCEC	All	All	+0.354	.027	2	view →
THCA	All	All	+0.141	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MYPOP–HNSC

Open the HNSC breakdown →