MYPOP

Across TCGA cell cohorts, MYPOP mutation is significantly associated with the RNA expression of many other genes, with 462 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYPOP-associated genes across cancer lineages are ADAM7, ODF1, and MAGEB18. Each is linked with MYPOP in more than 1 cancer types. Because this analysis shows association rather than direction, both MYPOP-to-partner and partner-to-MYPOP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM7 grouped by MYPOP-low versus MYPOP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYPOP→partner) and Y-score (partner→MYPOP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADAM7 →	+0.002	+2.345	<.001	.007	3	2
SKIN	ODF1 →	+0.020	+5.022	<.001	.002	3	1
STOMACH	MAGEB18 →	+0.238	+4.280	.001	.001	3	1
STOMACH	MBD3L3 →	+0.020	+3.794	<.001	.003	3	1
STOMACH	RTL4 →	+0.065	+3.794	.003	.003	3	1
STOMACH	OR56A5 →	+0.175	+3.794	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 462 associations by consensus.

ADAM7 by MYPOP expression — LARGE_INTESTINE

Explore this box plot interactively →