MYPN

Across TCGA patient cohorts, MYPN mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYPN-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and TIGAR. Each is linked with MYPN in more than 4 cancer types. Because this analysis shows association rather than direction, both MYPN-to-partner and partner-to-MYPN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by MYPN-low versus MYPN-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYPN→partner) and Y-score (partner→MYPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.370	-1.691	.012	.043	3	5
COAD	Caspase-7-cleavedD198 →	+1.063	+2.230	<.001	.006	3	3
LUSC	TIGAR →	+0.143	+1.630	.004	.020	3	2
LUSC	Claudin-7 →	+0.362	+2.584	.034	.010	3	2
UCEC	IGFBP2 →	-0.501	-1.000	.002	.048	3	2
LUAD	p62 Lck ligand →	+0.316	+2.186	.041	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

ATM by MYPN expression — COAD

Explore this box plot interactively →