MYPN

Across TCGA cell cohorts, MYPN mutation is significantly associated with the RNA expression of many other genes, with 455 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYPN-associated genes across cancer lineages are TFDP3, LCE2A, and OR2J1. Each is linked with MYPN in more than 1 cancer types. Because this analysis shows association rather than direction, both MYPN-to-partner and partner-to-MYPN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFDP3 grouped by MYPN-low versus MYPN-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYPN→partner) and Y-score (partner→MYPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TFDP3 →	+0.013	+5.000	<.001	.006	3	1
PANCREAS	LCE2A →	+0.033	+5.614	<.001	.002	3	1
PANCREAS	OR2J1 →	+0.006	+5.614	<.001	.002	3	1
PANCREAS	XKR4 →	+0.059	+5.000	<.001	.006	3	1
PANCREAS	OPN1MW3 →	+0.013	+5.614	<.001	.002	3	1
OESOPHAGUS	MS4A14 →	+0.053	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 455 associations by consensus.

TFDP3 by MYPN expression — PANCREAS

Explore this box plot interactively →