MYOZ1

Across TCGA patient cohorts, MYOZ1 mutation is significantly associated with the RNA expression of many other genes, with 239 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible MYOZ1-associated genes across cancer lineages are RN7SKP45, HERC2P1, and RN7SL565P. Each is linked with MYOZ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MYOZ1-to-partner and partner-to-MYOZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP45 grouped by MYOZ1-low versus MYOZ1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYOZ1→partner) and Y-score (partner→MYOZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SKP45 →	+0.296	+5.721	<.001	.001	3	2
UCEC	HERC2P1 →	+0.044	+3.805	<.001	.002	3	2
BLCA	RN7SL565P →	+0.083	+7.640	<.001	.009	3	2
SKCM	H1-5 →	+0.341	+3.220	.009	.009	3	2
SKCM	RNU1-21P →	+0.069	+4.351	<.001	.004	3	2
SKCM	TUBAP9 →	+0.037	+2.271	.004	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 239 associations by consensus.

RN7SKP45 by MYOZ1 expression — COAD

Explore this box plot interactively →