MYOG

Across TCGA cell cohorts, MYOG mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYOG-associated genes across cancer lineages are TMEM235, MBD3L5, and GJD2. Each is linked with MYOG in more than 1 cancer types. Because this analysis shows association rather than direction, both MYOG-to-partner and partner-to-MYOG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM235 grouped by MYOG-low versus MYOG-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYOG→partner) and Y-score (partner→MYOG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TMEM235 →	+0.012	+5.217	<.001	<.001	3	1
SKIN	MBD3L5 →	+0.021	+4.415	<.001	.007	3	1
LARGE_INTESTINE	GJD2 →	+0.006	+6.022	<.001	.001	3	1
LARGE_INTESTINE	HSFY2 →	+0.023	+4.977	<.001	.007	3	1
LARGE_INTESTINE	SLC15A5 →	+0.023	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

TMEM235 by MYOG expression — SKIN

Explore this box plot interactively →