MYO9B

Across TCGA patient cohorts, MYO9B mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYO9B-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and 4E-BP1. Each is linked with MYO9B in more than 4 cancer types. Because this analysis shows association rather than direction, both MYO9B-to-partner and partner-to-MYO9B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by MYO9B-low versus MYO9B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO9B→partner) and Y-score (partner→MYO9B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.626	-1.722	<.001	<.001	3	5
COAD	Caspase-7-cleavedD198 →	+1.309	+3.186	<.001	.009	3	4
UCEC	4E-BP1 →	+0.345	+1.722	<.001	<.001	3	3
LUSC	Bad_pS112 →	-0.174	-3.169	.029	.018	3	2
COAD	GAPDH →	+0.579	+1.749	.004	.049	3	2
COAD	Akt →	-0.452	-1.991	.015	.031	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

ATM by MYO9B expression — UCEC

Explore this box plot interactively →