MYO9B

Across TCGA pan-cancer cohorts, MYO9B RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MYO9B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MYO9B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MYO9B is over-expressed in tumor.

HNSC, KIRC, and KIRP are the cancer types where MYO9B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MYO9B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.418	<.001	12	view →
KIRC	Male	IV	+1.335	<.001	12	view →
KIRP	All	III,IV	+1.162	<.001	11	view →
LIHC	Female	II,III,IV	+1.440	<.001	9	view →
STAD	Male	II,III,IV	+1.295	<.001	9	view →
UCEC	All	II,III,IV	+0.732	.015	4	view →
BRCA	All	II,III,IV	+0.322	<.001	4	view →
BLCA	All	All	+0.322	.018	4	view →
CHOL	Female	All	+2.203	<.001	3	view →
ESCA	All	All	+1.092	.001	2	view →
COAD	Female	IV	+0.550	.046	1	view →
THCA	Female	III,IV	+0.370	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

MYO9B–HNSC

Open the HNSC breakdown →