MYO9A

Across TCGA patient cohorts, MYO9A mutation is significantly associated with the RNA expression of many other genes, with 6,530 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYO9A-associated genes across cancer lineages are RN7SL134P, GAPDH, and ZWINT. Each is linked with MYO9A in more than 3 cancer types. Because this analysis shows association rather than direction, both MYO9A-to-partner and partner-to-MYO9A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL134P grouped by MYO9A-low versus MYO9A-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO9A→partner) and Y-score (partner→MYO9A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RN7SL134P →	+0.275	+5.179	<.001	.001	3	4
UCEC	GAPDH →	+0.419	+1.958	<.001	<.001	3	4
UCEC	ZWINT →	+0.666	+1.969	<.001	<.001	3	4
SKCM	ATP1B2 →	-0.926	-1.537	.007	<.001	3	4
UCEC	AURKB →	+0.533	+1.326	<.001	<.001	3	4
UCEC	PGP →	+0.434	+1.823	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,530 associations by consensus.

RN7SL134P by MYO9A expression — READ

Explore this box plot interactively →