MYO9A

Across TCGA patient cohorts, MYO9A mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYO9A-associated genes across cancer lineages are ACVRL1, Cyclin-E1, and TAZ. Each is linked with MYO9A in more than 2 cancer types. Because this analysis shows association rather than direction, both MYO9A-to-partner and partner-to-MYO9A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACVRL1 grouped by MYO9A-low versus MYO9A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO9A→partner) and Y-score (partner→MYO9A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ACVRL1 →	-0.195	-2.983	.035	.034	3	3
LUAD	Cyclin-E1 →	+0.377	+3.169	.004	.019	3	3
COAD	TAZ →	+0.250	+3.459	<.001	.004	3	3
COAD	Caspase-7-cleavedD198 →	+0.956	+3.459	.001	.005	3	3
UCEC	GAPDH →	+0.356	+1.321	.011	.010	3	3
UCEC	JNK_pT183_Y185 →	-0.126	-1.289	.004	.018	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

ACVRL1 by MYO9A expression — COAD

Explore this box plot interactively →