MYO9A

Across TCGA cell cohorts, MYO9A mutation is significantly associated with the RNA expression of many other genes, with 1,510 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYO9A-associated genes across cancer lineages are DESI2, ZNF644, and DYNC1LI1. Each is linked with MYO9A in more than 2 cancer types. Because this analysis shows association rather than direction, both MYO9A-to-partner and partner-to-MYO9A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DESI2 grouped by MYO9A-low versus MYO9A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO9A→partner) and Y-score (partner→MYO9A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DESI2 →	+0.434	+2.043	.001	.001	3	3
LARGE_INTESTINE	ZNF644 →	+0.344	+2.043	.004	.001	3	3
LARGE_INTESTINE	DYNC1LI1 →	+0.375	+2.545	.002	<.001	3	3
BLOOD_Leukemia	PKNOX1 →	+0.527	+2.674	.001	.003	3	3
LARGE_INTESTINE	MRM3 →	+0.508	+3.321	.005	.003	3	3
LARGE_INTESTINE	ZZZ3 →	+0.575	+2.043	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,510 associations by consensus.

DESI2 by MYO9A expression — LARGE_INTESTINE

Explore this box plot interactively →