MYO5C

Across TCGA cell cohorts, MYO5C mutation is significantly associated with the RNA expression of many other genes, with 176 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYO5C-associated genes across cancer lineages are GSTA3, GSC2, and F11. Each is linked with MYO5C in more than 1 cancer types. Because this analysis shows association rather than direction, both MYO5C-to-partner and partner-to-MYO5C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSTA3 grouped by MYO5C-low versus MYO5C-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO5C→partner) and Y-score (partner→MYO5C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	GSTA3 →	+0.036	+4.129	<.001	.001	3	2
LARGE_INTESTINE	GSC2 →	+0.064	+2.425	<.001	.004	3	2
UPPER_AERODIGESTIVE_TRACT	F11 →	+0.153	+4.209	<.001	.006	3	2
BLOOD_Leukemia	ACTRT1 →	+0.015	+3.201	<.001	.005	3	2
BLOOD_Leukemia	PABPC5 →	+0.049	+2.772	.003	.004	3	2
BLOOD_Leukemia	GAGE12H →	+0.374	+2.922	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 176 associations by consensus.

GSTA3 by MYO5C expression — BONE

Explore this box plot interactively →