MYO5BP2

Across TCGA patient cohorts, MYO5BP2 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYO5BP2-associated genes across cancer lineages are CFHR2, MIR4736, and MIR5191. Each is linked with MYO5BP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MYO5BP2-to-partner and partner-to-MYO5BP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFHR2 grouped by MYO5BP2-low versus MYO5BP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO5BP2→partner) and Y-score (partner→MYO5BP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CFHR2 →	+0.096	+4.937	.004	.005	3	1
UCEC	MIR4736 →	+0.542	+6.049	<.001	.001	3	1
UCEC	MIR5191 →	+0.464	+5.226	<.001	.003	3	1
UCEC	MIR3181 →	+0.384	+5.335	<.001	.003	3	1
UCEC	RNU4-85P →	+0.549	+5.262	<.001	.001	3	1
UCEC	RNU4-56P →	+0.415	+5.582	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

CFHR2 by MYO5BP2 expression — UCEC

Explore this box plot interactively →