MYO3B

Across TCGA cell cohorts, MYO3B mutation is significantly associated with the RNA expression of many other genes, with 302 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYO3B-associated genes across cancer lineages are SLAMF1, GGTLC2, and TAS1R2. Each is linked with MYO3B in more than 1 cancer types. Because this analysis shows association rather than direction, both MYO3B-to-partner and partner-to-MYO3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLAMF1 grouped by MYO3B-low versus MYO3B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO3B→partner) and Y-score (partner→MYO3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLAMF1 →	+0.032	+2.485	.009	.002	3	2
OESOPHAGUS	GGTLC2 →	+0.458	+4.017	.001	.007	3	1
OESOPHAGUS	TAS1R2 →	+0.006	+4.017	<.001	.007	3	1
LUNG_SCLC	LYZL2 →	+0.020	+4.643	<.001	.004	3	1
LUNG_SCLC	OR5B12 →	+0.060	+4.523	<.001	.003	3	1
LUNG_SCLC	C16orf90 →	+0.066	+4.044	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 302 associations by consensus.

SLAMF1 by MYO3B expression — LARGE_INTESTINE

Explore this box plot interactively →