MYO1H

Across TCGA patient cohorts, MYO1H mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYO1H-associated genes across cancer lineages are STAT3_pY705, 4E-BP1, and Cyclin-B1. Each is linked with MYO1H in more than 2 cancer types. Because this analysis shows association rather than direction, both MYO1H-to-partner and partner-to-MYO1H results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by MYO1H-low versus MYO1H-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO1H→partner) and Y-score (partner→MYO1H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.303	-1.662	<.001	.009	3	3
UCEC	4E-BP1 →	+0.256	+2.321	.001	.005	3	3
UCEC	Cyclin-B1 →	+0.536	+2.050	.001	<.001	3	3
UCEC	FOXO3a_pS318_S321 →	-0.098	-1.706	.008	.003	3	2
UCEC	NF-kB-p65_pS536 →	-0.337	-1.906	.012	.014	3	2
UCEC	PCNA →	+0.255	+3.087	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

STAT3_pY705 by MYO1H expression — UCEC

Explore this box plot interactively →