MYO1B

Across TCGA patient cohorts, MYO1B mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYO1B-associated genes across cancer lineages are EGFR_pY1068, Caspase-7-cleavedD198, and A-Raf_pS299. Each is linked with MYO1B in more than 2 cancer types. Because this analysis shows association rather than direction, both MYO1B-to-partner and partner-to-MYO1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by MYO1B-low versus MYO1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO1B→partner) and Y-score (partner→MYO1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.287	-3.169	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.428	+2.189	.017	.001	3	3
UCEC	A-Raf_pS299 →	-0.132	-2.906	<.001	.001	3	2
UCEC	ERK2 →	+0.252	+1.999	<.001	<.001	3	2
UCEC	JNK2 →	+0.235	+2.933	<.001	<.001	3	2
UCEC	MEK1 →	+0.250	+1.807	.023	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

EGFR_pY1068 by MYO1B expression — UCEC

Explore this box plot interactively →