MYO1B

Across TCGA pan-cancer cohorts, MYO1B RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of MYO1B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MYO1B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MYO1B is over-expressed in tumor, although a few such as LUAD and KICH show the opposite, repressed pattern.

HNSC, LUAD, and STAD are the cancer types where MYO1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MYO1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+2.785	<.001	12	view →
LUAD	Female	II,III,IV	−0.908	<.001	11	view →
STAD	Male	II,III,IV	+1.582	<.001	8	view →
KICH	All	II,III,IV	−1.979	<.001	7	view →
LUSC	Female	II,III,IV	−1.222	<.001	7	view →
COAD	Male	All	+0.674	<.001	7	view →
BLCA	All	III,IV	+1.318	<.001	6	view →
LIHC	Female	All	−0.964	<.001	6	view →
BRCA	Female	II,III,IV	+0.312	.001	4	view →
ESCA	Female	All	+2.010	.007	2	view →
UCEC	All	II,III,IV	+1.276	.030	2	view →
READ	All	II,III,IV	+0.782	.035	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

MYO1B–HNSC

Open the HNSC breakdown →