MYO1B

Across TCGA cell cohorts, MYO1B mutation is significantly associated with the RNA expression of many other genes, with 187 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYO1B-associated genes across cancer lineages are NKX2-6, C14orf178, and GKAP1. Each is linked with MYO1B in more than 1 cancer types. Because this analysis shows association rather than direction, both MYO1B-to-partner and partner-to-MYO1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NKX2-6 grouped by MYO1B-low versus MYO1B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO1B→partner) and Y-score (partner→MYO1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NKX2-6 →	+0.217	+2.979	<.001	.007	3	2
BLOOD_Leukemia	C14orf178 →	+0.185	+3.212	<.001	<.001	3	2
LARGE_INTESTINE	GKAP1 →	+0.610	+3.082	.005	.007	3	2
LARGE_INTESTINE	B2M →	-2.114	-2.657	<.001	.002	3	2
URINARY_TRACT	OPN1MW2 →	+0.015	+4.087	<.001	.009	3	1
URINARY_TRACT	IFNA13 →	+0.145	+4.217	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 187 associations by consensus.

NKX2-6 by MYO1B expression — BLOOD_Leukemia

Explore this box plot interactively →