MYO1A

Across TCGA cell cohorts, MYO1A mutation is significantly associated with the RNA expression of many other genes, with 1,148 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYO1A-associated genes across cancer lineages are CCDC134, CBY1, and TRMU. Each is linked with MYO1A in more than 1 cancer types. Because this analysis shows association rather than direction, both MYO1A-to-partner and partner-to-MYO1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC134 grouped by MYO1A-low versus MYO1A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO1A→partner) and Y-score (partner→MYO1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCDC134 →	+0.760	+3.590	<.001	<.001	3	2
LARGE_INTESTINE	CBY1 →	+0.646	+3.036	<.001	<.001	3	2
LARGE_INTESTINE	TRMU →	+0.551	+2.459	.001	.006	3	2
LARGE_INTESTINE	FUZ →	-1.079	-3.169	.004	.009	3	2
LARGE_INTESTINE	TRIM37 →	+0.634	+2.265	<.001	.001	3	2
LARGE_INTESTINE	FAM149A →	+1.185	+3.252	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,148 associations by consensus.

CCDC134 by MYO1A expression — LARGE_INTESTINE

Explore this box plot interactively →