MYO15A

Across TCGA patient cohorts, MYO15A mutation is significantly associated with the RNA expression of many other genes, with 9,859 significant associations in total. STAD shows the largest number of these associations.

The most reproducible MYO15A-associated genes across cancer lineages are SNRPD1, CHAF1A, and AURKB. Each is linked with MYO15A in more than 5 cancer types. Because this analysis shows association rather than direction, both MYO15A-to-partner and partner-to-MYO15A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPD1 grouped by MYO15A-low versus MYO15A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO15A→partner) and Y-score (partner→MYO15A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SNRPD1 →	+0.491	+2.064	<.001	<.001	3	6
UCEC	CHAF1A →	+0.598	+1.972	<.001	<.001	3	6
COAD	AURKB →	+0.473	+2.763	<.001	<.001	3	6
UCEC	LONP1 →	+0.529	+1.622	<.001	<.001	3	6
STAD	ATP5PO →	+0.386	+2.128	<.001	<.001	3	6
STAD	FAM136A →	+0.405	+1.787	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,859 associations by consensus.

SNRPD1 by MYO15A expression — COAD

Explore this box plot interactively →