MYO15A

Across TCGA pan-cancer cohorts, MYO15A RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of MYO15A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MYO15A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MYO15A is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

HNSC, LUAD, and LUSC are the cancer types where MYO15A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MYO15A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.055	<.001	9	view →
LUAD	All	II,III,IV	−0.148	.001	7	view →
LUSC	Male	All	−0.179	<.001	6	view →
KIRC	All	All	+0.063	.002	6	view →
KICH	Male	All	−0.202	.004	5	view →
CHOL	All	All	+0.245	.028	2	view →
THCA	Male	All	−0.141	.021	2	view →
PRAD	All	All	−0.077	<.001	2	view →
READ	All	All	−0.046	.035	1	view →
LIHC	All	III,IV	−0.030	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

MYO15A–HNSC

Open the HNSC breakdown →