MYO15A

Across TCGA patient cohorts, MYO15A mutation is significantly associated with the total protein of many other genes, with 110 significant associations in total. COAD shows the largest number of these associations.

The most reproducible MYO15A-associated genes across cancer lineages are Cyclin-B1, PAI-1, and eIF4E. Each is linked with MYO15A in more than 4 cancer types. Because this analysis shows association rather than direction, both MYO15A-to-partner and partner-to-MYO15A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by MYO15A-low versus MYO15A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO15A→partner) and Y-score (partner→MYO15A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.459	+2.000	<.001	<.001	3	5
LUAD	PAI-1 →	+0.800	+2.584	.008	.011	3	5
UCEC	eIF4E →	+0.160	+2.150	.001	<.001	3	4
BLCA	FASN →	+0.501	+3.169	.010	.018	3	4
COAD	GAPDH →	+0.384	+2.012	.012	.004	3	4
COAD	Caspase-7-cleavedD198 →	+0.956	+2.584	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 110 associations by consensus.

Cyclin-B1 by MYO15A expression — UCEC

Explore this box plot interactively →