MYO15A

Across TCGA cell cohorts, MYO15A mutation is significantly associated with the RNA expression of many other genes, with 1,088 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYO15A-associated genes across cancer lineages are IL36A, ZNF18, and GPR101. Each is linked with MYO15A in more than 3 cancer types. Because this analysis shows association rather than direction, both MYO15A-to-partner and partner-to-MYO15A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL36A grouped by MYO15A-low versus MYO15A-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO15A→partner) and Y-score (partner→MYO15A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	IL36A →	+0.026	+5.643	<.001	.002	3	4
LARGE_INTESTINE	ZNF18 →	+0.502	+1.961	<.001	.004	3	4
OVARY	GPR101 →	+0.014	+3.084	<.001	.001	3	3
LARGE_INTESTINE	TTC19 →	+0.651	+3.584	<.001	<.001	3	3
LARGE_INTESTINE	MYBBP1A →	+0.654	+2.764	<.001	<.001	3	3
LARGE_INTESTINE	GPS2 →	+0.487	+1.969	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,088 associations by consensus.

IL36A by MYO15A expression — LUNG_SCLC

Explore this box plot interactively →