MYO10

Across TCGA cell cohorts, MYO10 mutation is significantly associated with the RNA expression of many other genes, with 1,832 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYO10-associated genes across cancer lineages are KSR2, CFHR2, and TBC1D15. Each is linked with MYO10 in more than 2 cancer types. Because this analysis shows association rather than direction, both MYO10-to-partner and partner-to-MYO10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KSR2 grouped by MYO10-low versus MYO10-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO10→partner) and Y-score (partner→MYO10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KSR2 →	+0.329	+3.386	.007	.001	3	3
BONE	CFHR2 →	+0.045	+4.169	<.001	.008	3	2
LARGE_INTESTINE	TBC1D15 →	+0.513	+2.451	.002	<.001	3	2
SKIN	FBXO21 →	+0.507	+3.502	.003	.001	3	2
SKIN	PHOSPHO2 →	+0.460	+3.321	.004	.003	3	2
SKIN	HELQ →	+0.409	+3.192	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,832 associations by consensus.

KSR2 by MYO10 expression — LARGE_INTESTINE

Explore this box plot interactively →