MYLK3

Across TCGA patient cohorts, MYLK3 mutation is significantly associated with the RNA expression of many other genes, with 3,232 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYLK3-associated genes across cancer lineages are COX6B1P7, GPN3, and ZNF850. Each is linked with MYLK3 in more than 2 cancer types. Because this analysis shows association rather than direction, both MYLK3-to-partner and partner-to-MYLK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX6B1P7 grouped by MYLK3-low versus MYLK3-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYLK3→partner) and Y-score (partner→MYLK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	COX6B1P7 →	+0.159	+6.914	<.001	<.001	3	3
LUAD	GPN3 →	+0.515	+3.193	.001	.009	3	3
UCEC	ZNF850 →	+0.437	+1.663	.001	.005	3	3
UCEC	PGP →	+0.407	+2.273	<.001	<.001	3	3
UCEC	BRI3BP →	+0.553	+2.283	<.001	<.001	3	3
UCEC	ZNF616 →	+0.331	+2.346	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,232 associations by consensus.

COX6B1P7 by MYLK3 expression — LIHC

Explore this box plot interactively →