MYLK3

Across TCGA pan-cancer cohorts, MYLK3 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated MYLK3 data layer compared with 11 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher MYLK3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated MYLK3 expression acts as an unfavorable survival marker, although some lineages such as ACC and LGG show a favorable association.

ACC, LGG, and LUSC are the cancer types where MYLK3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	III,IV	0.634	0.228	<.001	139	view →
LGG	OS	Median	All	0.866	0.754	<.001	42	view →
LUSC	OS	Tertile	II,III,IV	0.238	0.535	.001	37	view →
BRCA	OS	Median	II,III,IV	0.886	0.935	.003	31	view →
UCEC	OS	Tertile	III,IV	0.918	0.772	.002	30	view →
BLCA	DFS	Tertile	II,III,IV	0.444	0.579	.015	29	view →
KIRC	DFS	Median	All	0.904	0.838	.010	29	view →
THCA	OS	Tertile	III,IV	0.908	1.000	.007	27	view →
UVM	DFS	Tertile	All	0.358	0.694	.004	27	view →
LUAD	OS	Quartile	All	0.778	0.625	.017	18	view →
COAD	DFS	Tertile	III,IV	0.299	0.688	.002	11	view →
CESC	DFS	Median	III,IV	0.606	0.794	.024	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

MYLK3–ACC (OS)

Open the ACC breakdown →