MYLK3

Across TCGA patient cohorts, MYLK3 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYLK3-associated genes across cancer lineages are STAT3_pY705, HER2, and JNK_pT183_Y185. Each is linked with MYLK3 in more than 2 cancer types. Because this analysis shows association rather than direction, both MYLK3-to-partner and partner-to-MYLK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by MYLK3-low versus MYLK3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYLK3→partner) and Y-score (partner→MYLK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.363	-1.838	<.001	.007	3	3
SKCM	HER2 →	+0.233	+2.321	.021	.032	3	3
UCEC	JNK_pT183_Y185 →	-0.167	-1.847	.003	.007	3	2
UCEC	Ku80 →	+0.192	+1.261	.017	.029	3	2
UCEC	p62 Lck ligand →	+0.370	+1.807	<.001	.004	3	2
UCEC	Annexin-1 →	+0.565	+1.906	.001	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

STAT3_pY705 by MYLK3 expression — UCEC

Explore this box plot interactively →