MYLK3

Across TCGA cell cohorts, MYLK3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,389 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYLK3-associated GO terms across cancer lineages are Regulation of mRNA splicing, via spliceosome, Positive regulation of DNA-templated transcription initiation, and Positive regulation of double-strand break repair. Each is linked with MYLK3 in more than 10 cancer types. Because this analysis shows association rather than direction, both MYLK3-to-partner and partner-to-MYLK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mRNA splicing, via spliceosome grouped by MYLK3-low versus MYLK3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MYLK3→partner) and Y-score (partner→MYLK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of mRNA splicing, via spliceosome →	+0.064	+0.072	.001	.004	3	11
OVARY	Positive regulation of DNA-templated transcription initiation →	+0.049	+0.150	.001	.003	3	10
UPPER_AERODIGESTIVE_TRACT	Positive regulation of double-strand break repair →	+0.080	+0.232	<.001	.007	3	10
STOMACH	Regulation of TOR signaling →	+0.084	+0.585	<.001	.007	3	9
LUNG_SCLC	Negative regulation of autophagy →	+0.069	+0.683	.002	.006	3	9
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA-templated transcription initiation →	+0.080	+0.230	<.001	.005	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,389 associations by consensus.

Regulation of mRNA splicing, via spliceosome by MYLK3 expression — BONE

Explore this box plot interactively →