MYLK3

Across TCGA cell cohorts, MYLK3 mutation is significantly associated with the RNA expression of many other genes, with 349 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYLK3-associated genes across cancer lineages are OR9A2, OPCML, and IL25. Each is linked with MYLK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MYLK3-to-partner and partner-to-MYLK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR9A2 grouped by MYLK3-low versus MYLK3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYLK3→partner) and Y-score (partner→MYLK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR9A2 →	+0.012	+2.347	.001	.007	3	2
PANCREAS	OPCML →	+0.006	+5.000	<.001	.006	3	1
LUNG_NSCLC_LUAD	IL25 →	+0.009	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR4C46 →	+0.012	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	MT1HL1 →	+0.104	+4.681	<.001	.003	3	1
BLOOD_Lymphoma	REG3A →	+0.021	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 349 associations by consensus.

OR9A2 by MYLK3 expression — LARGE_INTESTINE

Explore this box plot interactively →