MYLK2

Across TCGA patient cohorts, MYLK2 mutation is significantly associated with the RNA expression of many other genes, with 3,366 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYLK2-associated genes across cancer lineages are S100A11P10, SEC14L6, and LINC00352. Each is linked with MYLK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MYLK2-to-partner and partner-to-MYLK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S100A11P10 grouped by MYLK2-low versus MYLK2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYLK2→partner) and Y-score (partner→MYLK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	S100A11P10 →	+0.092	+4.520	<.001	.004	3	3
UCEC	SEC14L6 →	-0.460	-1.574	.006	.005	3	3
BRCA	LINC00352 →	+0.302	+5.212	<.001	<.001	3	2
BRCA	RN7SL837P →	+0.093	+4.857	<.001	.004	3	2
BLCA	RNU6-511P →	+0.238	+3.376	.001	.007	3	2
BLCA	TRGJP1 →	+0.602	+3.495	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,366 associations by consensus.

S100A11P10 by MYLK2 expression — LUSC

Explore this box plot interactively →