MYLIP

Across TCGA patient cohorts, MYLIP mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYLIP-associated genes across cancer lineages are p27_pT198, P-Cadherin, and Caspase-7-cleavedD198. Each is linked with MYLIP in more than 1 cancer types. Because this analysis shows association rather than direction, both MYLIP-to-partner and partner-to-MYLIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by MYLIP-low versus MYLIP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYLIP→partner) and Y-score (partner→MYLIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.108	+2.459	.010	.019	3	2
UCEC	P-Cadherin →	-0.144	-3.459	.010	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.628	+2.019	.006	.017	3	2
UCEC	4E-BP1 →	+0.363	+3.459	<.001	.005	3	2
UCEC	Di-Ras3 →	-0.180	-3.308	.001	.009	3	2
UCEC	A-Raf_pS299 →	-0.180	-2.807	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

p27_pT198 by MYLIP expression — UCEC

Explore this box plot interactively →