MYL12A

Across TCGA cell cohorts, MYL12A mutation is significantly associated with the mutation status of many other genes, with 405 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYL12A-associated genes across cancer lineages are MYF6, ZNF430, and SP110. Each is linked with MYL12A in more than 1 cancer types. Because this analysis shows association rather than direction, both MYL12A-to-partner and partner-to-MYL12A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYF6 grouped by MYL12A-low versus MYL12A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYL12A→partner) and Y-score (partner→MYL12A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MYF6 →	+3.329	+3.799	.005	.005	1	2
LARGE_INTESTINE	ZNF430 →	+3.007	+3.584	.008	.008	1	2
LARGE_INTESTINE	SP110 →	+3.329	+3.799	.005	.005	1	2
LARGE_INTESTINE	PRSS23 →	+3.329	+3.799	.005	.005	1	2
LARGE_INTESTINE	RBM43 →	+3.007	+3.584	.008	.008	1	2
LARGE_INTESTINE	SYNJ2BP →	+4.329	+4.329	.001	.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 405 associations by consensus.

MYF6 by MYL12A expression — LARGE_INTESTINE

Explore this box plot interactively →